ATRT Investigators -
Jane Minturn, MD, PhD
Children’s Hospital of Philadelphia [Philadelphia, PA]
I am a member of the multidisciplinary Brain Tumor Program in the Cancer Center. Our team includes specialists in Neuro-Oncology, Neurology, Neurosurgery, Radiation Oncology, and Neuropsychology and Nurse Practitioners. There is a broad range of expertise that The Children's Hospital of Philadelphia brings to treating its patients with brain tumors.
My clinical and research interests are focused on developing personalized and disease-targeted therapeutics for embryonal tumors of the nervous system including ATRT. I am also interested in understanding the late effects of our therapies in long-term survivors of tumors, such as ATRT that primarily affect the developing brains of infants and very young children.
As part of our approach to identifying new treatments for children with brain tumors, we are members of the multi-institutional Pacific Pediatric Neuro-Oncology Consortium (PNOC), the Children's Oncology Group (COG) Phase 1 Consortium, and the home institution of the Children’s Brain Tumor Tissue Consortium (CBTTC). These groups are involved in collaborative pre-clinical and clinical efforts to bring new therapies for children with brain tumors.
There is a sense of urgency in our group — working collaboratively with laboratory scientists and drug development companies on accelerating the pace of discovering new treatments for children.
There is huge progress in getting promising drugs to children with cancer. Through our cooperative group consortia, the progress is more rapid than in past years, and Children's Hospital is a major part of the effort to help bring new agents to children with brain tumors.
Investigator of Clinical Trial: MV-NIS (NCT 02962167)
Alberto Broniscer, M.D.
UPMC Children’s Hospital of Pittsburgh [Pittsburgh, PA]
Director, Pediatric Neuro-Oncology Program, UPMC Children's Hospital of Pittsburgh
Visiting Professor of Pediatrics, University of Pittsburgh School of Medicine
Dr. Broniscer joined the faculty as the Director of the Pediatric Neuro Oncology Program at UPMC Children’s Hospital of Pittsburgh in August 2017. His clinical expertise is the treatment of infants, children, adolescents, and young adults with brain and spinal cord cancers. Once Dr. Broniscer completed his graduate and post-graduate training, he joined the faculty at St. Jude Children’s Research Hospital in July 2002. Dr. Broniscer worked at St. Jude as a full-time pediatric neuro-oncologist until July 2017.
Dr. Broniscer has a great interest in conducting research in different areas associated with brain and spinal cord cancers in children. He has conducted several single and multi-institutional Phase 1 and 2 clinical trials in the treatment of children with brain and spinal cord tumors & is particularly interested in developing new treatments based on biological characteristics of these tumors.
Although Dr. Broniscer was focused in the development of innovative clinical trials for children with high-grade gliomas, diffuse intrinsic pontine gliomas, and atypical teratoid rhabdoid tumors at St. Jude, he plans to continue these efforts for a broader range of brain and spinal cord tumors at the UPMC Children's Hospital of Pittsburgh. Dr. Broniscer has great interest in conducting clinical and molecular studies to increase the understanding about rare and aggressive types of pediatric brain cancers.